In recent years, there has been much interests in identification and characterization of numerous tumor relating substances including ectopic hormones, oncofetal antigens, or abnormal enzymes for the diagnosis and monitoring of malignant tumors.
But, practically so called cancer antigen, such as AFP, CEA, or TPA, which has been never used toward manufacturing anti-cancer antibody, while only used to compete the cancer tissue type specificity.
Nowadays, cancer antigen must be actually applied in the field of cancer treatment by means of the mediator or inducer for anti-cancer antibody formation. This study researched the alloimmunization effect of the serum components obtained from cancer developing animals, chemical carcinogen (NG: N-methyl-N´-nitroso-N-nitrosoguanidine) induced colon adenocarcinoma model, in 216 male rats, and gained following results:
1. In cancer producing rats, the CRP levels were maintained evenly high values althrough the experimen-
tal period; but serum TPA was gradually increased along sequential studies, while OCG and LDH
were increased in early acute phase and sooner decreased in late phase.
2. The individuals, those were allolmmunized by the serum acquired from cancer bearing rats, represented significantly high cancer rejection rate, especially in the group which was infused the serum of conspicuously high TPA concentration.
3. In the long;survivers and cancer resistance group, could observed neither high 9CG level nor in-creased LDH value, however the early deaths revealed extremely higher f3CG and LDH levels in contrast of relatively lower TPA concentration.
4. So, there was able to confirm the fact that not only cancer rejection antigenicity was presented in the serum of cancer developing individuals, but also could gained prominent allommunization effect utilizing such serum of high occurring TPA believing one of immunologic cancer rejectives by itself or mediation of antibody inducing effects.
|